Edited by the 1991 winners of the nobel prize in physiology or medicine this second edition includes new chapters covering such applications as capacitance measurements single cell pcr measurements whole cell recording from brain slices in combination with imaging techniques atomic force. The interpretation of single channel recordings david colquhoun and alan g hawkes 1 introduction the information in a single channel record is contained in the amplitudes of the openings the durations of the open and shut periods and in the order in which the. Single channel recording has become a widely used tool for the study of ion permeation mechanisms in biological membranes whereas the technique might have been considered an art after its introduct. The single channel recording technique has reached the status of a routine method and the view that conductance changes in biological membranes are caused by the openings and closings of ion channels is now almost universally accepted. Single channel recording yields information about unitary conductance and kinetic behaviour of ionic channels already partly investigated by classical voltage clamping and by noise analysis it is also leading to the discovery of new classes of ion channel
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